So it is possible things don't get better for Stafford this week. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates . Week 5 NFL game picks: Chiefs top Bills; Cardinals stay perfect with win over 49ers. But Minnesotas defense is tough. Cowboys' running game will be tested on Sunday (1:06) Herm Edwards and Tedy Bruschi discuss the outcome of what could be a high-scoring game in Dallas. Baby's pick: Cardinals 24, Bengals 21 What to know for fantasy: Najee Harris averaged over 4.0 yards per carry for the first time this season last week, but he failed to record a reception in Pickett's NFL debut. Betting nugget: Detroit has covered six straight road games, but it is 0-10-1 outright in its past 11 road games (0-9-1 under Dan Campbell). NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. Stat to know: The Niners' Jeff Wilson Jr. has scored multiple rushing touchdowns in two straight games. Betting nugget: San Francisco is 1-13-1 ATS and 6-9 outright in its past 15 games as a favorite (since Week 12 of 2014). But Trubisky is making his first career start on Monday Night Football. Swift likely out again vs. Patriots, source says, What to watch for: The Vikings' defense has given up 1,054 passing yards this season, seventh-most in the NFL, as it meanders through the adjustment process to coordinator Ed Donatell's 3-4 scheme. Watch the latest episode, Bold prediction: Cleveland running back Nick Chubb rushes for more than 100 yards against San Francisco's No. If that's the case, the Cardinals could pull off the upset. Betting nugget: The Broncos are 1-7 ATS in their past eight games. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round . No one really knows what to expect. The Bengals as a whole have an NFL-worst 2.8 yards per rush and NFL-low 1.5 yards before first contact. NFL picks, predictions for Week 5: Cardinals crush 49ers; Steelers stop The Raiders . What's more, it's Mayfield at quarterback for the Panthers this time, the same signal-caller Bosa made a point of terrorizing in 2019 with two sacks, a forced fumble and a fumble recovery. The Cowboys will be the third pass defense the Rams have faced so far ranked in the top seven, and their varied pass rush will make life difficult for Stafford. Las Vegas Raiders vs. Kansas City Chiefs picks, predictions NFL Week 5 What to know for fantasy: Austin Ekeler scored more fantasy points last week in Houston (34.9) than he did in the two weeks prior combined (31.7). For context, 5.2 yards per rush with McCoy on the field would rank fifth in the NFL among all teams this season, as opposed to 27th when McCoy isn't on the field. Meanwhile, Mahomes has thrown two interceptions, and the team has also lost two fumbles through four games. See Week 5 rankings. -- Eric D. Williams, Bold prediction: The Broncos have not intercepted a pass this season, but they will get their first one Sunday. That's not the attitude a winless team needs. Panthers QB Young all 'business now', Bold prediction: Bears rookie running back David Montgomery finally breaks through with 100 rushing yards. It prompted Packers coach Matt LaFleur to say this week that defensive coordinator Joe Barry needs to have his players "play more physical" and "in certain situations you might have to put an extra defender in the box." Because of the injuries in the Steelers' secondary, Josh Allen is primed to jump out to a big lead early and then let the ground attack go to work to run out the rest of the game. Herbert also totaled five touchdowns. We answered the biggest post-draft question for all 32, LB Barrett's 2-year-old daughter drowns in pool, Deion 'ashamed' after only 1 HBCU player drafted, Sources: NFL eyes May 11 to release schedule, Teams set NFL record with 43 trades during draft, Jets coach Saleh: Rodgers making 'presence felt', Cowboys scout emotional as team drafts his son, Rams use 'Mr. Betting nugget: Both Allen and Gardner Minshew II are 3-0 ATS in their careers as starters. It won't hold, though, as J.J. Watt & Co. make life miserable for the Falcons' offensive line. NFL Draft 2023: Ranking all 31 first-round picks as Eagles, Steelers On the flip side, the Packers might have to run the ball with Aaron Jones given the turf toe injury to Davante Adams, who caught two touchdown passes in the previous meeting in Dallas. This feels like it could go either way, but the edge goes to the home team. Our NFL Nation reporters bring us the biggest keys to every game and a bold prediction for each matchup. ), Jump to a matchup: "That's why he's one of the best [defensive] ends/outside 'backers ever." Wentz's seven picks are the most in the NFL. (1:17). Chicago knows how dangerous Minnesota's run game can be, so they'll stack the box to try to take away Dalvin Cook and make Cousins beat them with his arm. They also rank No. Theyll give up some yards and some plays. Betting nugget: Chicago is 4-12 ATS as an underdog since the start of last season. NFL Week 5 Early Odds, Picks & Predictions (2022) by Jason Radowitz | Sep, 29 2022 Before Week 4 begins, there's plenty of value with some Week 5 lines. His 43.1 QBR this season is also his worst through the first four games in that same time frame. 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades. -- Jamison Hensley. Read more. ET Thursday after a few more conversations with people around the NFL. How drawing plays benefits McVay, others Markquese Bell capitalizing on Cowboys opportunity, What to watch for: The Ravens have lost a franchise-worst five straight home games (by a total of 12 points), dating back to last season. The Bengals are allowing 8.6 yards per attempt, which is ideal for a team averaging 5.5 despite having Kyler Murray -- who has thrown for 300 yards in two of his first four games. What to know for fantasy: Breece Hall has a touchdown or six catches in all four games this season and seems to be trending in the direction of a lineup lock. The Patriots have allowed a league-high five touchdowns to tight ends this season. -- Rob Demovsky. NFL SPREAD TO WIN TOTAL Philadelphia Eagles -5.5 -227 o49 Arizona Cardinals +5.5 +175 u49 49ers 37, Panthers 15 Point spread: 49ers (-6.5) cover by winning by more than 6.5 points. Betting nugget: Baltimore has covered each of the past five meetings in Pittsburgh. Our experts share their favorite upset picks for Week 5, including an unsuspecting team who is 3-1 to start the year. Moody's pick: Jaguars 34, Texans 14 -- Jake Trotter, Bold prediction: The Chargers have yet to put together a 100-rushing yard performance this season, but that will change Sunday against the Browns. Stat to know: According to NFL Next Gen Stats data, Aaron Rodgers ranked first in completion percentage into tight windows in 2016. Cowboys D reaching elite levels of legendary Doomsday Defense? See Week 5 rankings. Getting back to what they do best -- stopping the run -- is paramount this week. Matchup rating: 42.5 | Spread: MIN -5.5 (43.5), What to watch for: How will Kirk Cousins perform vs. the Giants' 25th-ranked pass defense, which is allowing 279.5 yards per game. ET | FOX If the Jaguars have the same kind of issues along the defensive front they did last week, it'll be another long day. Read more. Read more. -- Jenna Laine. The NFL Week 5 schedule features a bevy of intriguing matchups including the Rams vs. Seahawks on Thursday Night Football in a matchup between two NFC East teams with championship aspirations; the Browns vs. Chargers in a battle between two surprising contenders in the AFC; the 49ers vs. Cardinals in a critical NFC West tilt featuring MVP They're tied for fourth with 25 explosive pass plays (16-plus yards), and Miami's banged-up secondary is giving up huge chunks in the passing game (31st in yards). -- Katherine Terrell, Bold prediction: Ryan Neal will take over for Josh Jones in the starting lineup and spark Seattle's struggling defense with a game-changing takeaway. The advantage for the Packers does not lie so much in the schematics, but the rest, which allowed four key offensive players more time to get ready. Finally, Seth Walder and Eric Moody give us final score picks for every game. Stat to know: Trevor Lawrence struggles under pressure, having the largest drop-off of any QB in QBR (-76) compared to when he's not pressured. Given the Colts' struggles protecting the quarterback (they've allowed 14 sacks, tied for fifth most in the league) and the Niners' ability to take advantage of porous offensive lines (nine sacks total against Seattle and Arizona), this would seem to be the type of game the 49ers can win. FPI prediction: PHI, 75.9% (by an average of 9.7 points), Matchup must-reads: Jalen Ramsey to the Eagles: What are the realistic odds? -- Jeff Legwold. Betting nugget: Atlanta has failed to cover 13 straight games against AFC opponents (1-12 outright). More NFL coverage , Bold prediction: The Bucs will hold Alvin Kamara under 100 all-purpose yards and under 45 rushing yards. Raiders hoping to reverse London trend by changing travel schedule Left with no defense, Jackson needs to carry Ravens this season, 1 p.m. NFL football pool, pick'em, office pool, confidence picks: Select the Giants 24, Chargers 23 -- Jordan Raanan, The Cardinals are 0-2 this season against NFC teams not in their division, but the biggest question mark will be whether the Cardinals can keep Carson Palmer on his feet. What to know for fantasy: After scoring 11 times in his first 14 games last season, Hopkins has scored just twice in his past seven games (playoffs included). It helps the Chargers are also winless (0-4) and can't run the ball (28th in NFL). This season, Cooks has zero 100-yard receiving games and has averaged just 53 yards per game. Walder's pick: Rams 27, Cowboys 17 In three games against the Packers, including playoffs, Elliott has run for 157, 125 and 116 yards on 79 carries. ET | CBS The Vikings are banged up on offense but probably still good enough to squeak out a close victory. Chargers 20, Giants 19 -- Eric Williams, The Giants are at home in a game they badly need to keep from imploding. -- Tim McManus. Week 5 brings some more great matchups and potential upsets. But Joe Flacco's struggles (one touchdown in his past 28 drives) and Baltimore's poor history traveling out west (five consecutive losses) make it difficult to have any confidence in the Ravens. NFL: Mahomes favorite for game's MVP Stat to know: Daniel Jones needs two passing touchdowns and 72 passing yards to have the most in each category by a Giants quarterback in his first three NFL starts since the 1970 merger. Commanders WR Curtis Samuel has 26 receptions this season, tied with Travis Kelce and Davante Adams for eighth most in the NFL. Neal has played well in the past while filling in for Jamal Adams and appears to be in line to get another opportunity, having replaced Jones in the fourth quarter of Seattle's win over Detroit. See Week 5 rankings. Top Week 5 NFL predictions One of the model's strongest Week 5 NFL picks is that the Titans (-2.5) cover against the Commanders in almost 60% of simulations. Wagoner's pick: 49ers 27, Browns 24 Bengals 13, Bills 9 -- Mike Rodak, The Bengals have a tough matchup against one of the league's best defenses (Buffalo is 10th overall), but it looks like their offense finally has begun to click in the past two weeks. Victor Cruz contends that Gardner Minshew is better equipped to lead his team to victory in the matchup with Panthers QB Kyle Allen. Wells' pick: Chiefs 41, Colts 24 Louis-Jacques' pick: Bills 14, Titans 10 Elliott is coming off the third-fewest rushing yards of his career, yet the Packers are allowing 142.3 yards per game and 5.0 yards per carry. ET | Fox Experts weigh in with analysis and provide premium picks for upcoming NFL games. Vikings 27, Bears 26 -- Jeff Dickerson, Cowboys' running game will be tested on Sunday (1:06), Week 5 NFL predictions: Scores for every game, Dolphins' Jaelan Phillips, teammates inspired by mentoring incarcerated teens, What adding Odell Beckham Jr. would mean for the New York Jets, Extending Vikings star Justin Jefferson: what it could cost, possible sticking points. NFL Week 5 Expert Picks - Straight Up - CBS Sports Click on each game for the game preview and CFN Prediction Week 5 NFL Expert Picks Read more. UPDATE: I made seven changes to my final mock draft -- starting with the No. The Chargers are 2-6 when the Broncos have intercepted Rivers at least twice and 5-11 when Denver has intercepted him at least once. 2023 NFL Draft props, picks: Michael Mayer Under 23.5 ET | Fox Betting nugget: Philadelphia is 3-0 ATS against Pittsburgh since 2008. The first round of the 2023 NFL Draft certainly had its moments, as three quarterbacks went within the first four picks and each of the major conferences had a player selected for the first time . -- Courtney Cronin. 2023 NFL mock draft: Matt Miller's seven-round predictions, picks - ESPN With DT Fletcher Cox still working through a calf injury, there's a chance Palmer will have a little more time to operate. See Week 5 rankings. The Colts, meanwhile, are scoring on 40% of their possessions, 11th best. See Week 5 rankings. -- David Newton, Bold prediction: San Francisco 49ers defensive end Nick Bosa will have three sacks in his second career game against the Panthers. Betting nugget: Mahomes is 7-1 outright and 6-2 ATS against Las Vegas. -- Mike Triplett, Everything you need this week: Chuck Pagano has never started a season 1-4 as coach of the Colts. 2023 NFL mock draft: Todd McShay's final first-round predictions - ESPN That doesnt mean theyll have an easy time against Houston rookie QB Deshaun Watson. Last week, we hit the Falcons at +3. The Colts' three losses have come to the same three teams that San Francisco has lost to -- Arizona, Los Angeles Rams and Seattle -- and Indianapolis lost those games by a combined 68 points. Tyrod Taylor has excelled in passing to Charles Clay and LeSean McCoy this season, but the Bengals boast the NFL's lowest yards per catch (6.49) by opposing tight ends and running backs. NFL Week 5 odds: Colts vs. Broncos | Giants vs. Packers | Steelers vs. Bills Chargers vs. Browns | Texans vs. Jaguars | Bears vs. Vikings Lions vs. Patriots | Seahawks vs. Saints | Dolphins. It wouldn't be a shock if they underestimate the Browns, but they have too many matchups in their favor to lose the game. The Jaguars were leading the NFL in rush defense until giving up 210 yards and four rushing touchdowns in a loss at Philadelphia last weekend. They're now +1.5. The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Winston already improving under 'QB whisperer' Bruce Arians, Yes, he's 2-0, but the Saints will need more from Bridgewater, Matthew Berry's Love/Hate for Week 5: How to make a trade, NFL experts predict: Week 5 upset picks, fantasy football flops and sleepers, How Watson's 'NFL experience' began as ball boy for the Falcons, TE Hooper could be the next Falcon to cash in, Taylor Lewan's return could be a boon for Titans' offense, Gore closing on No. -- Lindsey Thiry. The Carolina Panthers, with the No. The one thing that might help their offense is the return of running back Alvin Kamara, who said he's ready to roll this week. Week 5 NFL predictions: Scores for every game. Stat to know: The Eagles are the only team to win the turnover battle in every game this season. What to know for fantasy: Through four weeks, there were 44 players with at least 25 carries. Stat to know: The Vikings have allowed at least 300 yards in 12 straight games dating back to last season. Stat to know: Jared Goff is tied for the lead in passing touchdowns with 11. At 0-4, the Browns talked a good game all week, but there was a feeling that folks were looking over their shoulder. He is leading the NFL in sacks and pressures this year. Chicago head coach Matt Nagy is high on veteran backup quarterback Chase Daniel, who's starting in place of Mitchell Trubisky (left shoulder), but Nagy still wants to control the clock and pound the ball with Montgomery. 198 days ago NFL Week 4 of the 2022-23 NFL season has come to a close. -- Jamison Hensley, Bold prediction: Ja'Marr Chase will have more than 125 receiving yards. -- Courtney Cronin. Just like in life, it . Eli Manning beats Philip Rivers for the first time in his career. All-Time Longhorns NFL Draft Picks. See Week 5 rankings. Pick NFL winners straight up or against the spread and compete to win more than $14,400 in prizes! Chiefs 27, Texans 20 -- Sarah Barshop, The Vikings' defense aims to take advantage of Mitchell Trubiskys inexperience at quarterback by disguising coverages and playing hide-and-seek with its blitzes. Stat to know: Geno Smith has a 77.3 completion percentage this season, the highest by any QB through a team's first four games of a season in NFL history (min. He is the first player with nine sacks through the first four games of a season since Kabeer Gbaja-Biamila recorded nine in 2001. FPI prediction: LA, 65.1% (by an average of 4.7 points), Matchup must-reads: Jerry Jones: An 'injustice' not to give coach McCarthy credit Police report filed in Wagner tackle Cowboys D reaching elite levels of legendary Doomsday Defense? But he'll face a Redskins defense that, on third down, allows QBs to complete 87.2% of their throws and post a 140.5 passer rating. Experts predict Week 5 NFL upset picks, fantasy football - ESPN Steelers 24, Jaguars 10 -- Mike DiRocco, The Steelers' offense is poised to break out eventually; Ben Roethlisberger has only one completion of more than 40 yards this season -- which came in Week 2, his only home game. The good news for the Cowboys is that even after another ignominious loss dropped them to 1-3, they're still only a half-game out of first place in the NFC East, the only division with . 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades. NFL Expert Picks, Predictions, Lines: Week 5 - College Football News Predicting NFL Week 5 upset picks, fantasy football sleepers and flops The Bengals can build on their momentum here, and a win would make them 2-3 prior to their bye. ESPN Reporter Claims Aaron Rodgers Deal Affected NFL Schedule Release But theyll defeat him as they have other young quarterbacks except for Oaklands Derek Carr as a rookie in 2014. When the draft ended, there was a total of 43 trades, breaking . Betting nugget: Philadelphia is 10-0 all time against New York and 9-1 ATS. -- Michael Rothstein. NFL Week 5 picks, schedule, odds, injuries, stats, fantasy tips Read more. McClure's pick: Texans 24, Falcons 21 The Eagles' pass defense is vulnerable, but Luke Falk -- a dink-and-dunk passer -- doesn't have enough arm to exploit the matchup. They won't do anything to change that with a big win over the Giants. See Week 5 rankings. Newton's pick: Panthers 21, Jaguars 17 See Week 5 rankings. Texas has had 357 players selected in the NFL Draft. This could be Rodgers' breakout game. -- Brooke Pryor, NFL PrimeTime continues this postseason with extended highlights and analysis following the conclusion of each day's playoff games. The Steelers have allowed three touchdowns on passes that have traveled at least 25 yards in the air, tied for third worst in the NFL. That includes losses to the Titans and Colts in the past two weeks. See Week 5 rankings. They'll do just enough to keep things that way. Most important, Rodgers is 13-2 in those games, dating back to 2008. Expect the Texans to feed the Jaguars a heavy dose of Pierce, especially with run-game anchor Foley Fatukasi dealing with a quad injury. ESPN. Chiefs 24, Texans 20 -- Adam Teicher, Deshaun Watson and the Texans' offense made a big statement scoring 57 points against the Titans. FPI prediction: CAR, 57.9% (by an average of 2.8 points), Matchup must-reads: Fournette flourishes in Christian McCaffrey-type workload Amid defensive changes, Kuechly remains the Panthers' stopper Jaguars looking to cash in on Minshew mania Khan: No plan to trade CB Jalen Ramsey, 1 p.m. McManus's pick: Eagles 30, Jets 17 While the Chargers' running game has struggled, Herbert will always be a threat in the passing game. NFL odds, Vegas lines, picks, spreads, bets, predictions for Week 5 ET | NFL Network 2023 NFL draft cheat sheet: Prospect picks, rankings, stats - ESPN Rodgers hasn't topped 255 yards passing this season, and the Giants have the eighth-ranked pass defense. But Browns RB Nick Chubb leads the NFL in rushing first downs and rushes of 10-plus yards. It's time to look ahead to Week 5. Arizona has given up 17 sacks while the Eagles have 10 on the season, but Palmer called the Eagles' front seven one of the best he will face this year. The role is great, but don't forget DeAndre Hopkins' suspension has just two weeks left on it. NFL picks, predictions against the spread Week 5: Bengals top Ravens See Week 5 rankings. ET | Fox These two teams just played each other in the regular season finale last week when the Roughnecks won 25-9 despite Brandon Silvers, Max Borghi, Deontay Burnett, and Brycen Alleyne all sitting. Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs Patrick Mahomes says Andy Reid 'stole the show' in TV ad, 9:30 a.m. NFL: Notable Super Bowl betting trends See Week 5 rankings. That'll help the Texans continue their eight-game winning streak over the Jaguars. ARI-CIN | DEN-LAC | GB-DAL Read more. FPI prediction: HOU, 64.0% (by an average of 5.0 points), Matchup must-reads: How Watson's 'NFL experience' began as ball boy for the Falcons TE Hooper could be the next Falcon to cash in Quinn not worried about job, his staff, 1 p.m. FPI prediction: NO, 72.6% (by an average of 6.9 points), Matchup must-reads: The Seahawks have needed every bit of Geno Smith's unlikely success Andy Dalton gave Saints' offense a spark, but bigger issues loom after 1-3 start Saints' Alvin Kamara (rib) expects to play against Seahawks, What to watch for: Washington has done a nice job stopping the run the past two weeks against the Eagles and Cowboys, allowing an NFL-best 2.27 yards per carry and tying for second at 67 yards allowed during that stretch.